The Complete Spot Paintings 1986-2011 will include loans of the artist's works from public institutions and private collections, as well as paintings donated by Hirst himself.
The paintings will be displayed at all Gagosian Gallery sites during the same period, marking the first time that all eleven galleries have been dedicated to a body of work by the same artist.
Art lovers who are fans of Hirst's work might want to arrange their accommodation by checking out short stay apartments in Rome before the exhibition opens on January 12 next year.
The exhibition will be open until February 18, giving visitors to Rome a chance to see some of the most distinctive works in contemporary art.
Highlights will include Hirst's monumental canvases where no colour is ever repeated, alongside more recent works that comprise spots of just 1 millimetre in diameter.
The paintings will also be on display simultaneously at the Gagosian Gallery sites in New York, London, Paris, Los Angeles, Rome, Athens, Geneva, and Hong Kong.
Organisers hope that the exhibition will present Hirst's 'world of spots' in a truly global context.
A book entitled The Complete Spot Paintings 1986-2011 is due to be released to celebrate the launch of the exhibition at the eleven sites.
The illustrated text offers a complete reference guide to all of Hirst's spot paintings, beginning with his first produced in 1986 and continuing until the present day.
It comes as London's Tate Modern prepares to open the first major museum retrospective of Hirst's work in April next year.
Bristol-born Hirst, who won the Turner Prize in 1995, is one of the most famous contemporary artists in the world. He lives and works in London and Devon.
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