The Michelin-starred outlet, famed for its imaginative dishes and quirky food combinations, was ranked ninth-best in the world at an international awards ceremony.
The eatery opened with a major fanfare in February last year and has leapfrogged Mr Blumenthal's other restaurant, The Fat Duck, in Bray, Berkshire, which was number 13 on the list.
The rankings, which were based on a survey by Restaurant magazine, saw another London outlet reach the top 20, with The Ledbury coming in at 14th. The Notting Hill outlet climbed 20 places from its position in last year's top 50 list.
A statement from Restaurant magazine read: 'Blumenthal's historically influenced British cooking has proved hugely popular with both the local and international judging panels.'
Celebrity chef Mr Blumenthal, who has made several hit TV shows on Channel 4, said: 'I am really happy with the news. To have two restaurants side-by-side so high up the list is a brilliant result.
'The Fat Duck is better now than it has ever been and I am extremely proud of the whole team there, and the Dinner team have done a magnificent job since opening only a year ago.'
Brett Graham, chef at The Ledbury, said: 'A couple of years ago we never would have dreamed that we were in the list. We didn't even consider it actually and I was surprised we got an invitation last year.'
Topping the poll for the third year in a row was Noma in Copenhagen.
Restaurant said the attention to detail shown by its chef Rene Redzepi as well as his innovative approach are two of the reasons behind the restaurant's success. It described the chef of the two-Michelin starred restaurant as 'the standard bearer for the New Nordic movement'.
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